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Principal Scientist

Actively Reviewing the Applications

Metric Bio

On-site

Posted 3 weeks ago • Apply by June 16, 2026

Job Description

Metric Bio are partnering with a fast-growing CDMO in Pennsylvania to hire a Principal - Crystallization.

Location: Pennsylvania (on-site)

Employment Type: Full-time

Role Overview:

Lead solid-state and crystallization R&D for small molecule drug substances and intermediates, supporting preclinical and early clinical programs. Develop and optimize crystallization processes to control crystal form, particle size, morphology, and other key solid-state properties.

Key Responsibilities:

Lead solid-form screening and selection (polymorphs, salts, co-crystals) to identify optimal solid forms.
Design and develop robust crystallization processes and particle engineering strategies, including wet milling, jet milling, and other size-reduction techniques.
Implement PAT-enabled tools and modelling to improve process understanding and efficiency.
Collaborate closely with Process R&D, Analytical, QC, and cross-functional teams to support GMP and non-GMP programs.
Contribute to technology development, capability building, and continuous improvement initiatives.
Mentor junior scientists and support team expansion.
Maintain accurate experimental records and ensure compliance with GLP/GMP standards.

Qualifications:

PhD in Chemistry, Chemical Engineering, Pharmaceutical Sciences, or Materials Science.
5–10 years of experience in crystallization process development, solid-state chemistry, and/or pre-formulation studies.
Expertise in crystallization thermodynamics, kinetics, nucleation/growth, and solid-form characterization.
Hands-on experience with PXRD, DSC, TGA, PLM, DVS, PSD, HPLC, NMR, or related analytical techniques.
Strong problem-solving, communication, and project management skills.